Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion
نویسندگان
چکیده
Pasteurella multocida toxin (PMT) is a protein toxin found in toxigenic strains of Pasteurella multocida. PMT is the causative agent for atrophic rhinitis in pigs, a disease characterized by loss of nasal turbinate bones due to an inhibition of osteoblast function and an increase in osteoclast activity and numbers. Apart from this, PMT acts as a strong mitogen, protects from apoptosis and has an impact on the differentiation and function of immune cells. Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host's immune system are just beginning to unravel.
منابع مشابه
Pasteurella multocida Toxin Triggers RANKL-Independent Osteoclastogenesis
Bone remodeling is a continuous process to retain the structural integrity and function of the skeleton. A tight coupling is maintained between osteoclast-mediated resorption of old or damaged bones and osteoblast-mediated formation of new bones for bone homeostasis. While osteoblasts differentiate from mesenchymal stem cells, osteoclasts are hematopoietic in origin and derived from myeloid pre...
متن کاملImmune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene.
DNA vaccines were constructed with either a 5'-truncated or full-length, genetically detoxified toxin gene from Pasteurella multocida and two different DNA vaccine vectors, distinguished by the presence or absence of a secretion signal sequence. Optimal PMT-specific antibody responses and spleen cell secretion of interferon-gamma following immunization of mice were achieved with pMM4, the const...
متن کاملPasteurella multocida Toxin Activates Various Heterotrimeric G Proteins by Deamidation
Pasteurella multocida produces a 146-kDa protein toxin (Pasteurella multocida toxin, PMT), which stimulates diverse cellular signal transduction pathways by activating heterotrimeric G proteins. PMT deamidates a conserved glutamine residue of the α-subunit of heterotrimeric G proteins that is essential for GTP-hydrolysis, thereby arresting the G protein in the active state. The toxin substrates...
متن کاملActivation of Gαi and subsequent uncoupling of receptor-Gαi signaling by Pasteurella multocida toxin
Joachim H. C. Orth, Ines Fester, Inga Preuß, Laura Agnoletto, Brenda A. Wilson and Klaus Aktories Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-LudwigsUniversität Freiburg, D-79104 Freiburg, Germany, Department of Microbiology, University of Illinois at Urbana-Champaign, 601 South Goodwin Avenue, B128 CLSL, Urbana, IL 61801, USA. Running title: Pasteurella mult...
متن کاملSelective Membrane Redistribution and Depletion of Gαq-Protein by Pasteurella multocida Toxin
Pasteurella multocida toxin (PMT), the major virulence factor responsible for zoonotic atrophic rhinitis, is a protein deamidase that activates the alpha subunit of heterotrimeric G proteins. Initial activation of G alpha-q-coupled phospholipase C-beta-1 signaling by PMT is followed by uncoupling of G alpha-q-dependent signaling, causing downregulation of downstream calcium and mitogenic signal...
متن کامل